Magnesium Infusions for Persistent Pain: What The Research Shows

NMDA Receptor Antagonism: Clinical studies show magnesium blocks NMDA receptors involved in pain signaling and central sensitization, helping reduce hyperexcitability in chronic pain conditions

Perioperative Pain Reduction: Meta-analyses demonstrate that perioperative magnesium significantly reduces postoperative pain scores and opioid consumption by up to 24% following surgery

Neuropathic Pain Relief: Research indicates magnesium can help reduce pain, allodynia, and hyperalgesia in conditions like postherpetic neuralgia by normalizing overactive pain pathways

Muscle Relaxation Effects: Studies show magnesium helps relax muscle tension and spasm—key components of many chronic pain conditions—by regulating calcium channels involved in muscle contraction

Anti-inflammatory Properties: Evidence suggests magnesium modulates inflammatory pathways, reducing the release of pro-inflammatory cytokines that contribute to persistent pain states

Added Benefits of Intravenous Magnesium

Improved Sleep Quality: Research shows magnesium helps regulate neurotransmitters directly involved in sleep, with many pain patients reporting deeper, more restorative sleep following treatment

Reduced Anxiety: Studies demonstrate magnesium's significant calming effect on the nervous system, helping to reduce anxiety symptoms that can amplify pain perception

Enhanced Energy Production: Magnesium's role in cellular energy creation leads many patients to experience improved energy levels and reduced fatigue—common issues in chronic pain conditions

Fibromyalgia Management: Clinical evidence indicates magnesium therapy can help alleviate widespread pain associated with fibromyalgia by normalizing pain receptor activity and improving sleep quality

Pelvic Pain Relief: Recent reviews suggest good evidence supporting magnesium's efficacy for treating pelvic pain associated with endometriosis and related conditions